Continuous Crystallization in Pharmaceutical Manufacturing

Allan S. Myerson, Ph.D.

Crystallization from solution is an important separation and purification process used in the chemical, pharmaceutical and food industry.  In addition to control of purity, crystallization processes must also produce crystals of a desired size distribution, shape and crystal form (polymorph).   The development of a robust and scale-able crystallization process is thus crucial in the development of pharmaceutical processes 

This lecture will focus on new and novel continuous crystallization techniques.  These will include novel crystallizer configurations, the use of recycle streams and methods of process intensification in which crystallization and drug product manufacture are combined.